What is Vitiligo?
Vitiligo is a long term skin condition that causes depigmentation of the skin. It can affect skin on any part of the body. It can also affect hair, the inside of the mouth and even the eyes. It affects people of all ethnicities but is more noticeable in people with darker skin. It is not life threatening or contagious
There is no cure for vitiligo. The goal of treatment is to stop or slow the progression of pigment loss and attempt to restore color to the skin.
What determines Skin Colour?
Melanin that is produced by cells called melanocytes determines the colour of skin, hair and eyes. Melanocytes are present in the skin, mucous membranes, eyes, and inner ear. The loss of melanocytes alters both the structure and function of these organs and results in the loss of colour. While it was traditionally thought that Vitiligo-affected areas lacked melanocytes, the pigment-producing cells, recent studies have demonstrated that such areas do contain these cells though they are non-functional. Vitiligo affects both men and women and can develop progressively over time.
What are the causes of the disease?
The etiology of Vitiligo is far from clear. Several of the main hypotheses about the causes of the disease are: Genetics: There is scientific evidence suggesting that Vitiligo may be inherited in humans. This, however, is not according to the Mendelian genetic basis but possibly due to the simultaneous involvement of two or more genes. Autoimmunity: Literature also suggests that Vitiligo may be an autoimmune disorder. In a recent study, mice vaccinated with a recombinant vaccine virus encoding a protein that resides in a pigment producing part of melanocytes developed skin depigmentation resembling human Vitiligo three weeks after the second immunisation. Growth Factor Deprivation: It was postulated that bFGF deprived in the skin could be the cause of Vitiligo. It is this hypothesis upon which a new method of treatment was developed and tried successfully.
Implications of the disease?
The patchy depigmentation of skin is disfiguring and can often produce psychological trauma leading to depression or social withdrawal of affected individuals. The risk of sunburn of the affected skin also increases due to the lack of protective pigments.
Vitiligo generally affects about 1% of the world’s population without racial, sexual or regional differences. Some reports do, however, suggest that incidence in India, Egypt and Japan is higher, ranging from 1.25% to 6% of the population.
Traditional ways of treatment?
Traditional therapies for Vitiligo, based on ancient Atharva Veda observations, include photo chemotherapy with topical/oral psoralens, followed by exposure to ultraviolet light sunlight. This combined treatment is known as PUVA and is based on the observation in Atharva Veda more than 3000 years ago. It is reported that these treatments result in limited success. Even in patients who have a good response to medical treatment methods, the hands, fingers, feet, ankles and lips frequently do not re-pigment. In fast spreading cases of Vitiligo, skin creams and/or ointments with corticosteroids are prescribed. This is to limit the spread of the pigment loss by reducing the loss of melanocytes by autoimmune antibodies to melanocytes. Vitiligo can also be treated through homeopathic medicine. The success rate of these traditional methods of treatment is, however, not satisfactory. These methods are not completely effective, and they produce undesirable side effects. There is indeed a need to develop a new method of treatment for this disorder.
What is Melgain®?
Melgain® is peptide-based lotion preparation, for external use only. Melgain® is composed with 10 amino acids (Deca-peptide). Melgain® is an effective drug in the treatment of Vitiligo.
How it acts?
Melgain® acts as a. Mitogen to Melanocytes b. As chemokinetic & chemotactic (thus Melanocytes proliferate at margins and migrate & populate the Vitiligo patch) c. As a stimulator of Melgain® biosynthesis by Melanocytes which proliferate in response to Melgain.
Decapeptide (Basic Fibroblast Growth Factor)
- • Contains 10 amino acids
• 3 skin penetration enhancers
What is the active ingredient in Melgain® and what concentration does it possess?
Melgain® contain Deca-peptide as an active ingredient and it possesses 1 mg per 1 ml.
What are the package sizes available in the Market?
Melgain® is available in 2ml, 5ml and 10ml vials with roll-on applicators.
How to Use Melgain®?
Gently shake the bottle. Invert the bottle and roll a thin layer onto the white patches of the skin once a day. The best time of application is 1-2 hours before going to bed. After application, do not touch the treated white patches for one hour. Expose the white patches to bright sunlight for approximately 10-15 minutes the next day. If you are not able to achieve exposure to sunlight on occasion, please continue applying treatment daily. If you cannot receive sunlight exposure frequently, your doctor may recommend alternative exposure such as through ultraviolet lamps. Apply Melgain® once daily as above.
How Long Should You Use Melgain®?
The duration of treatment depends on a number of factors. Normally, re-pigmentation can be seen on the borders or inside the white patch (as dots of pigment) in 3 to 6 months depending on the age of the white patch. In over 80% of study participants, full re-pigmentation was noted after one year of Melgain® use as mono-therapy. Recently developed patches and children respond faster.
Is it available in the market?
Do Doctors Recommend it?
Yes. Doctors recommend Melgain®? as the most effective drug for Vitiligo treatment. Melgain® is one of the leading brands in India for the treatment of Vitiligo.